Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Rocio Villa; Claudia Ferrer-Carbonell; Caroline E. Paul

doi:10.1039/d3cy00541k

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Rocio Villa, Claudia Ferrer-Carbonell, Caroline E. Paul^*

^*Corresponding author for this work

BT/Biocatalysis

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Abstract

Biocatalytic asymmetric reduction of alkenes in organic solvent is attractive for enantiopurity and product isolation, yet remains under developed. Herein we demonstrate the robustness of an ene reductase immobilised on Celite for the reduction of activated alkenes in micro-aqueous organic solvent. Full conversion was obtained in methyl t-butyl ether, avoiding hydrolysis and racemisation of products. The immobilised ene reductase showed reusability and a scale-up demonstrated its applicability.

Original language	English
Pages (from-to)	5530-5535
Number of pages	6
Journal	Catalysis Science and Technology
Volume	13
Issue number	19
DOIs	https://doi.org/10.1039/d3cy00541k
Publication status	Published - 2023

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d3cy00541kFinal published version, 1.53 MBLicence: CC BY

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abstract = "Biocatalytic asymmetric reduction of alkenes in organic solvent is attractive for enantiopurity and product isolation, yet remains under developed. Herein we demonstrate the robustness of an ene reductase immobilised on Celite for the reduction of activated alkenes in micro-aqueous organic solvent. Full conversion was obtained in methyl t-butyl ether, avoiding hydrolysis and racemisation of products. The immobilised ene reductase showed reusability and a scale-up demonstrated its applicability.",

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T1 - Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

AU - Villa, Rocio

AU - Ferrer-Carbonell, Claudia

AU - Paul, Caroline E.

PY - 2023

Y1 - 2023

N2 - Biocatalytic asymmetric reduction of alkenes in organic solvent is attractive for enantiopurity and product isolation, yet remains under developed. Herein we demonstrate the robustness of an ene reductase immobilised on Celite for the reduction of activated alkenes in micro-aqueous organic solvent. Full conversion was obtained in methyl t-butyl ether, avoiding hydrolysis and racemisation of products. The immobilised ene reductase showed reusability and a scale-up demonstrated its applicability.

AB - Biocatalytic asymmetric reduction of alkenes in organic solvent is attractive for enantiopurity and product isolation, yet remains under developed. Herein we demonstrate the robustness of an ene reductase immobilised on Celite for the reduction of activated alkenes in micro-aqueous organic solvent. Full conversion was obtained in methyl t-butyl ether, avoiding hydrolysis and racemisation of products. The immobilised ene reductase showed reusability and a scale-up demonstrated its applicability.

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U2 - 10.1039/d3cy00541k

DO - 10.1039/d3cy00541k

M3 - Article

AN - SCOPUS:85174958254

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JO - Catalysis Science and Technology

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ER -

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Abstract

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