Biocatalytic Reduction Reactions from a Chemist's Perspective

Frank Hollmann*, Diederik J. Opperman, Caroline E. Paul

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)
29 Downloads (Pure)


Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we describe the synthetic state-of-the-art and potential of enzymes that catalyse reductions, ranging from carbonyl, enone and aromatic reductions to reductive aminations.

Original languageEnglish
Pages (from-to)5644-5665
JournalAngewandte Chemie - International Edition
Issue number11
Publication statusPublished - 2020


  • bioreductions
  • dehydrogenases
  • hydrogenation
  • reductases
  • reductive amination


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