Biocatalytic Reduction Reactions from a Chemist's Perspective

Frank Hollmann, Diederik J. Opperman, Caroline E. Paul

Research output: Contribution to journalReview articleScientificpeer-review

9 Citations (Scopus)
6 Downloads (Pure)

Abstract

Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we describe the synthetic state-of-the-art and potential of enzymes that catalyse reductions, ranging from carbonyl, enone and aromatic reductions to reductive aminations.

Original languageEnglish
Pages (from-to)2-24
JournalAngewandte Chemie - International Edition
Volume59
DOIs
Publication statusPublished - 2020

Keywords

  • bioreductions
  • dehydrogenases
  • hydrogenation
  • reductases
  • reductive amination

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