Biosynthesis of cyclic ketones by a H2O2 self-sufficient cascade reaction

Bin Wu, Xiangyun Wang, Bo Yang, Yunjian Ma*, Frank Hollmann, Yonghua Wang

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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In the present work we propose a bienzymatic cascade for the oxyfunctionalisation of cycloalkanes to cyclic alcohols/cyclic ketones. By combining a H2O2-dependent peroxygenase with a O2-consuming and H2O2-producing alcohol oxidase an overall aerobic oxidation system was established. A convincing proof-of-concept is presented and some current limitations are outlined.

Original languageEnglish
Article number113396
Number of pages6
JournalMolecular Catalysis
Publication statusPublished - 2023


  • Alcohol oxidase
  • Cyclohexanone
  • HO self-cycling
  • Unspecific peroxygenase


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