Biosynthesis of cyclic ketones by a H2O2 self-sufficient cascade reaction

Bin Wu; Xiangyun Wang; Bo Yang; Yunjian Ma; Frank Hollmann; Yonghua Wang

doi:10.1016/j.mcat.2023.113396

Biosynthesis of cyclic ketones by a H₂O₂ self-sufficient cascade reaction

Bin Wu, Xiangyun Wang, Bo Yang, Yunjian Ma^*, Frank Hollmann, Yonghua Wang

^*Corresponding author for this work

BT/Biocatalysis

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Abstract

In the present work we propose a bienzymatic cascade for the oxyfunctionalisation of cycloalkanes to cyclic alcohols/cyclic ketones. By combining a H₂O₂-dependent peroxygenase with a O₂-consuming and H₂O₂-producing alcohol oxidase an overall aerobic oxidation system was established. A convincing proof-of-concept is presented and some current limitations are outlined.

Original language	English
Article number	113396
Number of pages	6
Journal	Molecular Catalysis
Volume	547
DOIs	https://doi.org/10.1016/j.mcat.2023.113396
Publication status	Published - 2023

Keywords

Alcohol oxidase
Cyclohexanone
HO self-cycling
Unspecific peroxygenase

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10.1016/j.mcat.2023.113396

1-s2.0-S2468823123004790-mainFinal published version, 1.43 MBLicence: CC BY

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abstract = "In the present work we propose a bienzymatic cascade for the oxyfunctionalisation of cycloalkanes to cyclic alcohols/cyclic ketones. By combining a H2O2-dependent peroxygenase with a O2-consuming and H2O2-producing alcohol oxidase an overall aerobic oxidation system was established. A convincing proof-of-concept is presented and some current limitations are outlined.",

keywords = "Alcohol oxidase, Cyclohexanone, HO self-cycling, Unspecific peroxygenase",

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journal = "Molecular Catalysis",

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T1 - Biosynthesis of cyclic ketones by a H2O2 self-sufficient cascade reaction

AU - Wu, Bin

AU - Wang, Xiangyun

AU - Yang, Bo

AU - Ma, Yunjian

AU - Hollmann, Frank

AU - Wang, Yonghua

PY - 2023

Y1 - 2023

N2 - In the present work we propose a bienzymatic cascade for the oxyfunctionalisation of cycloalkanes to cyclic alcohols/cyclic ketones. By combining a H2O2-dependent peroxygenase with a O2-consuming and H2O2-producing alcohol oxidase an overall aerobic oxidation system was established. A convincing proof-of-concept is presented and some current limitations are outlined.

AB - In the present work we propose a bienzymatic cascade for the oxyfunctionalisation of cycloalkanes to cyclic alcohols/cyclic ketones. By combining a H2O2-dependent peroxygenase with a O2-consuming and H2O2-producing alcohol oxidase an overall aerobic oxidation system was established. A convincing proof-of-concept is presented and some current limitations are outlined.

KW - Alcohol oxidase

KW - Cyclohexanone

KW - HO self-cycling

KW - Unspecific peroxygenase

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U2 - 10.1016/j.mcat.2023.113396

DO - 10.1016/j.mcat.2023.113396

M3 - Article

AN - SCOPUS:85165602197

SN - 2468-8231

VL - 547

JO - Molecular Catalysis

JF - Molecular Catalysis

M1 - 113396

ER -

Biosynthesis of cyclic ketones by a H₂O₂ self-sufficient cascade reaction

Abstract

Keywords

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