Deterministic Global Optimization with Artificial Neural Networks Embedded

Artur M. Schweidtmann, Alexander Mitsos*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

117 Citations (Scopus)


Artificial neural networks are used in various applications for data-driven black-box modeling and subsequent optimization. Herein, we present an efficient method for deterministic global optimization of optimization problems with artificial neural networks embedded. The proposed method is based on relaxations of algorithms using McCormick relaxations in a reduced space (Mitsos et al. in SIAM J Optim 20(2):573–601, 2009) employing the convex and concave envelopes of the nonlinear activation function. The optimization problem is solved using our in-house deterministic global solver. The performance of the proposed method is shown in four optimization examples: an illustrative function, a fermentation process, a compressor plant and a chemical process. The results show that computational solution time is favorable compared to a state-of-the-art global general-purpose optimization solver.

Original languageEnglish
Pages (from-to)925-948
JournalJournal of Optimization Theory and Applications
Issue number3
Publication statusPublished - 2019
Externally publishedYes


  • Machine learning
  • MAiNGO
  • McCormick relaxations
  • Multilayer perceptron
  • Surrogate-based optimization


Dive into the research topics of 'Deterministic Global Optimization with Artificial Neural Networks Embedded'. Together they form a unique fingerprint.

Cite this