Effect of hyaluronic acid on the struvite crystallization: A structural, morphological, and thermal analysis study

Sevgi Polat*, Huseyin Burak Eral

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)
112 Downloads (Pure)


The struvite crystals constitute one of the common types of urinary stones. Such stones are also referred as “infection stones” due to their tendency to cause infections in urinary tract. A considerable effort has been placed to identify natural or synthetic crystal-growth modifiers for this kind of urinary stone in literature, yet macromolecules commonly found in urine have been underexplored. In the present study, we experimentally focus on how hyaluronic acid, a protein commonly found in urine, alters the struvite crystallization in aqueous solution and in an artificial urine media. By gradually adding ammonium dihydrogen phosphate to a solution containing magnesium chloride hexahydrate, reactive crystallization is carried out in a well-mixed and thermostated vessel at 37 °C. The resulting struvite crystals are characterized structurally by XRD and FTIR as well as morphologically and in terms of their surface charge. In addition, the thermal decomposition behavior of the struvite with and without hyaluronic acid and released volatile products were simultaneously investigated using a TGA/FTIR system. The average activation energy calculated using the Friedman method was 49.2 ± 5.1 kJ/mol. The results of the kinetic and thermodynamic analyses showed that decomposition of the struvite crystals was endothermic and followed the multiple stage reaction mechanism.

Original languageEnglish
Article number126734
Number of pages11
JournalJournal of Crystal Growth
Publication statusPublished - 2022


  • A1. shape parameters
  • A1. TGA/FTIR
  • A1. thermal kinetics
  • B1. crystallization
  • B1. Struvite


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