High-definition imaging of carotid artery wall dynamics

Pieter Kruizinga*, Frits Mastik, Stijn C.H. van den Oord, Arend F.L. Schinkel, Johannes G. Bosch, Nico de Jong, Gijs van Soest, Anton F.W. van der Steen

*Corresponding author for this work

    Research output: Contribution to journalArticleScientificpeer-review

    34 Citations (Scopus)
    112 Downloads (Pure)


    The carotid artery (CA) is central to cardiovascular research, because of the clinical relevance of CA plaques as culprits of stroke and the accessibility of the CA for cardiovascular screening. The viscoelastic state of this artery, essential for clinical evaluation, can be assessed by observing arterial deformation in response to the pressure changes throughout the cardiac cycle. Ultrasound imaging has proven to be an excellent tool to monitor these dynamic deformation processes. We describe how a new technique called high-frame-rate ultrasound imaging captures the tissue deformation dynamics throughout the cardiac cycle in unprecedented detail. Local tissue motion exhibits distinct features of sub-micrometer displacements on a sub-millisecond time scale. We present a high-definition motion analysis technique based on plane wave ultrasound imaging able to capture these features. We validated this method by screening a group of healthy volunteers and compared the results with those for two patients known to have atherosclerosis to illustrate the potential utility of this technique.

    Original languageEnglish
    Pages (from-to)2392-2403
    JournalUltrasound in Medicine and Biology
    Issue number10
    Publication statusPublished - 2014


    • Carotid artery
    • High-frame-rate ultrasound
    • Plane wave imaging
    • Pulse wave velocity
    • Tissue Doppler


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