TY - JOUR
T1 - High-definition imaging of carotid artery wall dynamics
AU - Kruizinga, Pieter
AU - Mastik, Frits
AU - van den Oord, Stijn C.H.
AU - Schinkel, Arend F.L.
AU - Bosch, Johannes G.
AU - de Jong, Nico
AU - van Soest, Gijs
AU - van der Steen, Anton F.W.
PY - 2014
Y1 - 2014
N2 - The carotid artery (CA) is central to cardiovascular research, because of the clinical relevance of CA plaques as culprits of stroke and the accessibility of the CA for cardiovascular screening. The viscoelastic state of this artery, essential for clinical evaluation, can be assessed by observing arterial deformation in response to the pressure changes throughout the cardiac cycle. Ultrasound imaging has proven to be an excellent tool to monitor these dynamic deformation processes. We describe how a new technique called high-frame-rate ultrasound imaging captures the tissue deformation dynamics throughout the cardiac cycle in unprecedented detail. Local tissue motion exhibits distinct features of sub-micrometer displacements on a sub-millisecond time scale. We present a high-definition motion analysis technique based on plane wave ultrasound imaging able to capture these features. We validated this method by screening a group of healthy volunteers and compared the results with those for two patients known to have atherosclerosis to illustrate the potential utility of this technique.
AB - The carotid artery (CA) is central to cardiovascular research, because of the clinical relevance of CA plaques as culprits of stroke and the accessibility of the CA for cardiovascular screening. The viscoelastic state of this artery, essential for clinical evaluation, can be assessed by observing arterial deformation in response to the pressure changes throughout the cardiac cycle. Ultrasound imaging has proven to be an excellent tool to monitor these dynamic deformation processes. We describe how a new technique called high-frame-rate ultrasound imaging captures the tissue deformation dynamics throughout the cardiac cycle in unprecedented detail. Local tissue motion exhibits distinct features of sub-micrometer displacements on a sub-millisecond time scale. We present a high-definition motion analysis technique based on plane wave ultrasound imaging able to capture these features. We validated this method by screening a group of healthy volunteers and compared the results with those for two patients known to have atherosclerosis to illustrate the potential utility of this technique.
KW - Carotid artery
KW - High-frame-rate ultrasound
KW - Plane wave imaging
KW - Pulse wave velocity
KW - Tissue Doppler
UR - http://www.scopus.com/inward/record.url?scp=84926244476&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2014.03.009
DO - 10.1016/j.ultrasmedbio.2014.03.009
M3 - Article
C2 - 25088760
VL - 40
SP - 2392
EP - 2403
JO - Ultrasound in Medicine & Biology
JF - Ultrasound in Medicine & Biology
SN - 0301-5629
IS - 10
ER -