Influence of distance and incident angle on light intensities in intravascular optical coherence tomography pullback runs

Shengnan Liu, Jeroen Eggermont, Ron Wolterbeek, Boudewijn P.F. Lelieveldy, J Dijkstra

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

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Intravascular optical coherence tomography (IVOCT) is an intravascular imaging modality which enables the visualization arterial structures at the micro-structural level. The interpretations of these structures is mainly on the basis of relative image intensities. However, even for homogeneous tissue light intensities can differ. In this study the incident light intensity is modeled to be related to the catheter position. Two factors, the distance between catheter and inner lumen wall as well as the incident angle of the light upon the lumen wall, are considered. A three-level hierarchical model is constructed to statistically validate this model to include the potential effect of different pullbacks and/or frame numbers. The model is solved using 169 images out of 9 pull-backs recorded with a St.Jude Medical IVOCT system. F-tests results indicate that both the distance and the incident angle contribute to the model statistically significantly with p < 0.001. Based on the results from the statistical analysis, a potential compensation method is introduced to normalize the IVOCT intensities for the catheter position effects and small shadows
Original languageEnglish
Title of host publicationProceedings of SPIE Photonic Therapeutics and Diagnostics XII
EditorsHyun Wook Kang, Guillermo J. Tearney, Kenton W. Gregory, Laura Marcu, Melissa C. Skala, Paul J. Campagnola, Bernard Choi, Nikiforos Kollias, Haishan Zeng, Andreas Mandelis, Brian J.F. Wong, Justus F. Ilgner
Place of PublicationBellingham, WA
Number of pages6
ISBN (Print)9781628419245
Publication statusPublished - 2016
EventSPIE BIOS: Photonic Therapeutics and Diagnostics XII - San Francisco, United States
Duration: 13 Feb 201618 Feb 2016

Publication series

NameProceedings of SPIE
ISSN (Electronic)0277-786X


ConferenceSPIE BIOS
CountryUnited States
CitySan Francisco


  • angle of incidence
  • catheter position
  • compensation
  • distance
  • hierarchical linear regression
  • intravascular optical coherence tomography
  • statistical analysis

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