Natural deep eutectic solvents as performance additives for biocatalysis

Özlem Erol, Frank Hollmann*

*Corresponding author for this work

Research output: Chapter in Book/Conference proceedings/Edited volumeChapterScientific

5 Citations (Scopus)
63 Downloads (Pure)


Following ionic liquids, (natural) deep eutectic solvents ((NA)DES) are receiving significant attention as performance additives for biocatalytic reactions. (NA)DES are increasingly evaluated as solvents to replace water in hydrolase-catalyzed esterification reactions thereby shifting the reaction equilibrium. They also frequently outperform water in terms of solubility properties of hydrophobic reagents and thereby enable higher space-time yields. Furthermore, (NA)DES frequently exceed stabilizing effects on enzymes and thereby enable more robust (and therefore economically more attractive) biocatalytic syntheses. In this contribution, we will summarize and critically evaluate the recent literature on (NA)DES-supported biocatalysis.

Original languageEnglish
Title of host publicationEutectic Solvents and Stress in Plants
EditorsRobert Verpoorte, Geert-Jan Witkamp, Young Hae Choi
PublisherAcademic Press
ISBN (Print)9780128216910
Publication statusPublished - 2021

Publication series

NameAdvances in Botanical Research
ISSN (Print)0065-2296

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.


  • Biocatalysis
  • Deep eutectic solvents
  • Enzymes


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