Following ionic liquids, (natural) deep eutectic solvents ((NA)DES) are receiving significant attention as performance additives for biocatalytic reactions. (NA)DES are increasingly evaluated as solvents to replace water in hydrolase-catalyzed esterification reactions thereby shifting the reaction equilibrium. They also frequently outperform water in terms of solubility properties of hydrophobic reagents and thereby enable higher space-time yields. Furthermore, (NA)DES frequently exceed stabilizing effects on enzymes and thereby enable more robust (and therefore economically more attractive) biocatalytic syntheses. In this contribution, we will summarize and critically evaluate the recent literature on (NA)DES-supported biocatalysis.