Naturally occurring shear waves in healthy volunteers and hypertrophic cardiomyopathy patients

Mihai Strachinaru, Johan G. Bosch, Lennart van Gils, Bas M. van Dalen, Arend F. L. Schinkel, Antonius F. W. van der Steen, Nico de Jong, Michelle Michels, Hendrik J. Vos, Marcel L. Geleijnse

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Abstract

We apply a high frame rate (over 500 Hz) tissue Doppler method to measure the propagation velocity of naturally occurring shear waves (SW) generated by aortic and mitral valves closure. The aim of this work is to demonstrate clinical relevance. We included 45 healthy volunteers and 43 patients with hypertrophic cardiomyopathy (HCM). The mitral SW (4.68 ± 0.66 m/s) was consistently faster than the aortic (3.51 ± 0.38 m/s) in all volunteers (p < 0.0001). In HCM patients, SW velocity correlated with E/e’ ratio (r = 0.346, p = 0.04 for aortic SW and r = 0.667, p = 0.04 for mitral SW). A subgroup of 20 volunteers were matched for age and gender to 20 HCM patients. In HCM, the mean velocity of 5.1 ± 0.7 m/s for the aortic SW (3.61 ± 0.46 m/s in matched volunteers, p < 0.0001) and 6.88 ± 1.12 m/s for the mitral SW(4.65 ± 0.77 m/s in matched volunteers, p < 0.0001). A threshold of 4 m/s for the aortic SW correctly classified pathologic myocardium with a sensitivity of 95% and specificity of 90%. Naturally occurring SW can be used to assess differences between normal and pathologic myocardium.

Original languageEnglish
Pages (from-to)1977-1986
Number of pages10
JournalUltrasound in Medicine and Biology
Volume45
Issue number8
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • Cardiac shear wave
  • Cardiac elastography
  • High frame rate
  • Tissue Doppler

Cite this