New type of basket stationary bed reactor for heterogeneous biocatalysis

Dominika Stradomska, Daria Świętochowska, Robert Kubica, Ulf Hanefeld, Katarzyna Szymańska*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review


Effectiveness of catalytic processes using heterogeneous biocatalysts depends not only on the activity of the enzyme, but also on the efficiency of the used reactor. In this paper, we present a novel design of a basket reactor with a stationary catalyst bed (StatBioChem). The developed design was compared to a commercially available rotating bed reactor (SpinChem®). The biocatalysts used were invertase and acyltransferase from Mycobacterium smegmatis (MsAcT) immobilised on macroporous silica supports. The obtained values of initial reaction rate, both in the reaction of saccharose hydrolysis and 2,2-dimethyl-1,3-propanediol (NPG) transesterification, were twice higher for the StatBioChem reactor. A similar relationship was also observed regarding the process efficiency expressed as STY.

Original languageEnglish
Article number109590
JournalChemical Engineering and Processing - Process Intensification
Publication statusPublished - 2023

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public


  • A novel design of reactor
  • Heterogeneous biocatalysts
  • Intensification of mass and heat transfer
  • Process intensification
  • Rotating bed reactor
  • Stationary bed reactor


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