New type of basket stationary bed reactor for heterogeneous biocatalysis

Dominika Stradomska; Daria Świętochowska; Robert Kubica; Ulf Hanefeld; Katarzyna Szymańska

doi:10.1016/j.cep.2023.109590

New type of basket stationary bed reactor for heterogeneous biocatalysis

Dominika Stradomska, Daria Świętochowska, Robert Kubica, Ulf Hanefeld, Katarzyna Szymańska^*

^*Corresponding author for this work

BT/Biocatalysis

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Abstract

Effectiveness of catalytic processes using heterogeneous biocatalysts depends not only on the activity of the enzyme, but also on the efficiency of the used reactor. In this paper, we present a novel design of a basket reactor with a stationary catalyst bed (StatBioChem). The developed design was compared to a commercially available rotating bed reactor (SpinChem®). The biocatalysts used were invertase and acyltransferase from Mycobacterium smegmatis (MsAcT) immobilised on macroporous silica supports. The obtained values of initial reaction rate, both in the reaction of saccharose hydrolysis and 2,2-dimethyl-1,3-propanediol (NPG) transesterification, were twice higher for the StatBioChem reactor. A similar relationship was also observed regarding the process efficiency expressed as STY.

Original language	English
Article number	109590
Journal	Chemical Engineering and Processing - Process Intensification
Volume	194
DOIs	https://doi.org/10.1016/j.cep.2023.109590
Publication status	Published - 2023

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public

Keywords

A novel design of reactor
Heterogeneous biocatalysts
Intensification of mass and heat transfer
Process intensification
Rotating bed reactor
Stationary bed reactor

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10.1016/j.cep.2023.109590

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title = "New type of basket stationary bed reactor for heterogeneous biocatalysis",

abstract = "Effectiveness of catalytic processes using heterogeneous biocatalysts depends not only on the activity of the enzyme, but also on the efficiency of the used reactor. In this paper, we present a novel design of a basket reactor with a stationary catalyst bed (StatBioChem). The developed design was compared to a commercially available rotating bed reactor (SpinChem{\textregistered}). The biocatalysts used were invertase and acyltransferase from Mycobacterium smegmatis (MsAcT) immobilised on macroporous silica supports. The obtained values of initial reaction rate, both in the reaction of saccharose hydrolysis and 2,2-dimethyl-1,3-propanediol (NPG) transesterification, were twice higher for the StatBioChem reactor. A similar relationship was also observed regarding the process efficiency expressed as STY.",

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AU - Kubica, Robert

AU - Hanefeld, Ulf

AU - Szymańska, Katarzyna

N1 - Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public

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AB - Effectiveness of catalytic processes using heterogeneous biocatalysts depends not only on the activity of the enzyme, but also on the efficiency of the used reactor. In this paper, we present a novel design of a basket reactor with a stationary catalyst bed (StatBioChem). The developed design was compared to a commercially available rotating bed reactor (SpinChem®). The biocatalysts used were invertase and acyltransferase from Mycobacterium smegmatis (MsAcT) immobilised on macroporous silica supports. The obtained values of initial reaction rate, both in the reaction of saccharose hydrolysis and 2,2-dimethyl-1,3-propanediol (NPG) transesterification, were twice higher for the StatBioChem reactor. A similar relationship was also observed regarding the process efficiency expressed as STY.

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New type of basket stationary bed reactor for heterogeneous biocatalysis

Abstract

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Keywords

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