Photoelectroenzymatic Oxyfunctionalization on Flavin-Hybridized Carbon Nanotube Electrode Platform

Da Som Choi; Yan Ni; Elena Fernández-Fueyo; Minah Lee; Frank Hollmann; Chan Beum Park

doi:10.1021/acscatal.6b03453

Photoelectroenzymatic Oxyfunctionalization on Flavin-Hybridized Carbon Nanotube Electrode Platform

Da Som Choi, Yan Ni, Elena Fernández-Fueyo, Minah Lee, Frank Hollmann^*, Chan Beum Park

^*Corresponding author for this work

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Peroxygenases are very promising catalysts for oxyfunctionalization reactions. Their practical applicability, however, is hampered by their sensitivity against the oxidant (H₂O₂), therefore necessitating in situ generation of H₂O₂. Here, we report a photoelectrochemical approach to provide peroxygenases with suitable amounts of H₂O₂ while reducing the electrochemical overpotential needed for the reduction of molecular oxygen to H₂O₂. When tethered on single-walled carbon nanotubes (SWNTs) under illumination, flavins allowed for a marked anodic shift of the oxygen reduction potential in comparison to pristine SWNT and/or nonilluminated electrodes. This flavin-SWNT-based photoelectrochemical platform enabled peroxygenases-catalyzed, selective hydroxylation reactions.

Original language	English
Pages (from-to)	1563-1567
Number of pages	5
Journal	ACS Catalysis
Volume	7
Issue number	3
DOIs	https://doi.org/10.1021/acscatal.6b03453
Publication status	Published - 3 Mar 2017

Bibliographical note

Accepted Author Manuscript

Keywords

flavins
heme proteins
oxyfunctionalization
peroxygenases
photoelectrochemistry

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10.1021/acscatal.6b03453

Revised Manuscript_ACS Catalysis_cs-2016-03453b_no highlight (2)Accepted author manuscript, 510 KB

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title = "Photoelectroenzymatic Oxyfunctionalization on Flavin-Hybridized Carbon Nanotube Electrode Platform",

abstract = "Peroxygenases are very promising catalysts for oxyfunctionalization reactions. Their practical applicability, however, is hampered by their sensitivity against the oxidant (H2O2), therefore necessitating in situ generation of H2O2. Here, we report a photoelectrochemical approach to provide peroxygenases with suitable amounts of H2O2 while reducing the electrochemical overpotential needed for the reduction of molecular oxygen to H2O2. When tethered on single-walled carbon nanotubes (SWNTs) under illumination, flavins allowed for a marked anodic shift of the oxygen reduction potential in comparison to pristine SWNT and/or nonilluminated electrodes. This flavin-SWNT-based photoelectrochemical platform enabled peroxygenases-catalyzed, selective hydroxylation reactions.",

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AU - Choi, Da Som

AU - Ni, Yan

AU - Fernández-Fueyo, Elena

AU - Lee, Minah

AU - Hollmann, Frank

AU - Park, Chan Beum

N1 - Accepted Author Manuscript

PY - 2017/3/3

Y1 - 2017/3/3

N2 - Peroxygenases are very promising catalysts for oxyfunctionalization reactions. Their practical applicability, however, is hampered by their sensitivity against the oxidant (H2O2), therefore necessitating in situ generation of H2O2. Here, we report a photoelectrochemical approach to provide peroxygenases with suitable amounts of H2O2 while reducing the electrochemical overpotential needed for the reduction of molecular oxygen to H2O2. When tethered on single-walled carbon nanotubes (SWNTs) under illumination, flavins allowed for a marked anodic shift of the oxygen reduction potential in comparison to pristine SWNT and/or nonilluminated electrodes. This flavin-SWNT-based photoelectrochemical platform enabled peroxygenases-catalyzed, selective hydroxylation reactions.

AB - Peroxygenases are very promising catalysts for oxyfunctionalization reactions. Their practical applicability, however, is hampered by their sensitivity against the oxidant (H2O2), therefore necessitating in situ generation of H2O2. Here, we report a photoelectrochemical approach to provide peroxygenases with suitable amounts of H2O2 while reducing the electrochemical overpotential needed for the reduction of molecular oxygen to H2O2. When tethered on single-walled carbon nanotubes (SWNTs) under illumination, flavins allowed for a marked anodic shift of the oxygen reduction potential in comparison to pristine SWNT and/or nonilluminated electrodes. This flavin-SWNT-based photoelectrochemical platform enabled peroxygenases-catalyzed, selective hydroxylation reactions.

KW - flavins

KW - heme proteins

KW - oxyfunctionalization

KW - peroxygenases

KW - photoelectrochemistry

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Photoelectroenzymatic Oxyfunctionalization on Flavin-Hybridized Carbon Nanotube Electrode Platform

Abstract

Bibliographical note

Keywords

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