Potential of MRI in radiotherapy mediated by small conjugates and nanosystems

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
33 Downloads (Pure)

Abstract

Radiation therapy has made tremendous progress in oncology over the last decades due to advances in engineering and physical sciences in combination with better biochemical, genetic and molecular understanding of this disease. Local delivery of optimal radiation dose to a tumor, while sparing healthy surrounding tissues, remains a great challenge, especially in the proximity of vital organs. Therefore, imaging plays a key role in tumor staging, accurate target volume delineation, assessment of individual radiation resistance and even personalized dose prescription. From this point of view, radiotherapy might be one of the few therapeutic modalities that relies entirely on high-resolution imaging. Magnetic resonance imaging (MRI) with its superior soft-tissue resolution is already used in radiotherapy treatment planning complementing conventional computed tomography (CT). Development of systems integrating MRI and linear accelerators opens possibilities for simultaneous imaging and therapy, which in turn, generates the need for imaging probeswith therapeutic components. In this review, we discuss the role of MRI in both external and internal radiotherapy focusing on the most important examples of contrast agents with combined therapeutic potential.

Original languageEnglish
Article number59
Number of pages19
JournalInorganics
Volume7
Issue number5
DOIs
Publication statusPublished - 2019

Keywords

  • Contrast agents
  • Gadolinium
  • Ionizing radiation
  • Iron oxide nanoparticles
  • Magnetic resonance imaging
  • Radiosensitization
  • Relaxivity
  • Theranostics
  • Therapeutic radionuclides

Fingerprint Dive into the research topics of 'Potential of MRI in radiotherapy mediated by small conjugates and nanosystems'. Together they form a unique fingerprint.

Cite this