Abstract
Cancer cell migration between different body parts is the driving force behind cancer metastasis, which causes mortality of patients. Migration of cancer cells often proceeds by penetration through narrow cavities in possibly stiff tissues. In our previous work [12], a model for the evolution of cell geometry is developed, and in the current study we use this model to investigate whether followers among (cancer) cells benefit from leading (cancer) cells during transmigration through micro-channels and cavities. Using Wilcoxon’s signed-rank text on the data collected from Monte Carlo simulations, we conclude that the transmigration time for the stalk cell is significantly smaller than for the leading cell with a p-value less than 0.0001, for the modelling set-up that we have used in this study.
Original language | English |
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Title of host publication | Lecture Notes in Computational Vision and Biomechanics |
Subtitle of host publication | Selected Papers from the 17th International Symposium CMBBE and 5th Conference on Imaging and Visualization |
Publisher | Springer |
Pages | 112-122 |
Number of pages | 11 |
ISBN (Print) | 978-3-031-10015-4 |
DOIs | |
Publication status | Published - 2023 |
Event | 17th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and the 5th Conference on Imaging and Visualization - online symposium Duration: 7 Sept 2021 → 9 Sept 2021 Conference number: 17 |
Publication series
Name | Lecture Notes in Computational Vision and Biomechanics |
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Volume | 38 |
ISSN (Print) | 2212-9391 |
ISSN (Electronic) | 2212-9413 |
Conference
Conference | 17th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and the 5th Conference on Imaging and Visualization |
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Abbreviated title | CMBBE 2021 |
Period | 7/09/21 → 9/09/21 |
Bibliographical note
Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-careOtherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Keywords
- Agent-based model
- Cell metastasis
- Evolution of cell geometry
- Morphoelasticity