Production of Co-58m in a siphon-style liquid target on a medical cyclotron

L. Mues genannt Koers; S. W. McNeil; V. Radchenko; E. Paulssen; C. Hoehr

doi:10.1016/j.apradiso.2023.110734

Production of Co-58m in a siphon-style liquid target on a medical cyclotron

L. Mues genannt Koers, S. W. McNeil, V. Radchenko, E. Paulssen, C. Hoehr^*

^*Corresponding author for this work

RST/Applied Radiation & Isotopes

Research output: Contribution to journal › Article › Scientific › peer-review

28 Downloads (Pure)

Abstract

We present the production of ^58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (^⁵⁸m/gCo and ⁵⁶Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA⁻¹ for ^58mCo with a separation recovery of (75 ± 2) % of cobalt after one separation step utilizing LN-resin.

Original language	English
Article number	110734
Number of pages	9
Journal	Applied Radiation and Isotopes
Volume	195
DOIs	https://doi.org/10.1016/j.apradiso.2023.110734
Publication status	Published - 2023

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

Cobalt-58m
Cyclotron production
Liquid target
Meitner-Auger therapy
Radiometal
Small medical cyclotron

Access to Document

10.1016/j.apradiso.2023.110734

1-s2.0-S0969804323000878-mainFinal published version, 2.57 MB

Cite this

@article{78189e420239486a95c8a5f5abec6641,

title = "Production of Co-58m in a siphon-style liquid target on a medical cyclotron",

abstract = "We present the production of 58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (58m/gCo and 56Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA−1 for 58mCo with a separation recovery of (75 ± 2) % of cobalt after one separation step utilizing LN-resin.",

keywords = "Cobalt-58m, Cyclotron production, Liquid target, Meitner-Auger therapy, Radiometal, Small medical cyclotron",

author = "{Mues genannt Koers}, L. and McNeil, {S. W.} and V. Radchenko and E. Paulssen and C. Hoehr",

note = "Green Open Access added to TU Delft Institutional Repository {\textquoteleft}You share, we take care!{\textquoteright} – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. ",

year = "2023",

doi = "10.1016/j.apradiso.2023.110734",

language = "English",

volume = "195",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier",

}

TY - JOUR

T1 - Production of Co-58m in a siphon-style liquid target on a medical cyclotron

AU - Mues genannt Koers, L.

AU - McNeil, S. W.

AU - Radchenko, V.

AU - Paulssen, E.

AU - Hoehr, C.

N1 - Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

PY - 2023

Y1 - 2023

N2 - We present the production of 58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (58m/gCo and 56Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA−1 for 58mCo with a separation recovery of (75 ± 2) % of cobalt after one separation step utilizing LN-resin.

AB - We present the production of 58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (58m/gCo and 56Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA−1 for 58mCo with a separation recovery of (75 ± 2) % of cobalt after one separation step utilizing LN-resin.

KW - Cobalt-58m

KW - Cyclotron production

KW - Liquid target

KW - Meitner-Auger therapy

KW - Radiometal

KW - Small medical cyclotron

UR - http://www.scopus.com/inward/record.url?scp=85149175152&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2023.110734

DO - 10.1016/j.apradiso.2023.110734

M3 - Article

AN - SCOPUS:85149175152

SN - 0969-8043

VL - 195

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 110734

ER -

Production of Co-58m in a siphon-style liquid target on a medical cyclotron

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this