Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design

Samy Abo Seada; Anke W. van der Eerden; Agnita J.W. Boon; Juan A. Hernandez-Tamames

doi:10.1016/j.nicl.2023.103506

Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design

Samy Abo Seada, Anke W. van der Eerden, Agnita J.W. Boon, Juan A. Hernandez-Tamames^*

^*Corresponding author for this work

ImPhys/Vos group

Research output: Contribution to journal › Review article › peer-review

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Abstract

Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.

Original language	English
Article number	103506
Number of pages	12
Journal	NeuroImage: Clinical
Volume	39
DOIs	https://doi.org/10.1016/j.nicl.2023.103506
Publication status	Published - 2023

Keywords

Atypical parkinsonisms
DTI
MSA
Multi-modal
Parkinson
PSP
QSM
Quantitative MRI

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10.1016/j.nicl.2023.103506

1-s2.0-S2213158223001973-mainFinal published version, 6.66 MBLicence: CC BY-NC-ND

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title = "Quantitative MRI protocol and decision model for a {\textquoteleft}one stop shop{\textquoteright} early-stage Parkinsonism diagnosis: Study design",

abstract = "Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.",

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AU - Seada, Samy Abo

AU - van der Eerden, Anke W.

AU - Boon, Agnita J.W.

AU - Hernandez-Tamames, Juan A.

PY - 2023

Y1 - 2023

N2 - Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.

AB - Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.

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KW - DTI

KW - MSA

KW - Multi-modal

KW - Parkinson

KW - PSP

KW - QSM

KW - Quantitative MRI

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JO - NeuroImage: Clinical

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Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design

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Keywords

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