Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces

Mauricio Cruz Saldívar; Robin Petrus Elias  Veeger; Edwin Tay; Michele Fenu; Maria Klimopoulou; Gerjo van Osch; Lidy Fratila-Apachitei; Zjenja Doubrovski; Mohammad Javad Mirzaali; Amir Abbas Zadpoor; null More Authors

doi:10.1016/j.xcrp.2023.101552

Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces

Mauricio Cruz Saldívar, Robin Petrus Elias Veeger, Edwin Tay, Michele Fenu, Maria Klimopoulou, Gerjo van Osch, Lidy Fratila-Apachitei, Zjenja Doubrovski, Mohammad Javad Mirzaali^*, Amir Abbas Zadpoor, More Authors

^*Corresponding author for this work

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Abstract

Living organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D-printed voxels from either hard or soft phase to decode this relationship. Combining micro/macroscale experiments and finite element simulations, a power law model emerges, linking voxel arrangement to composite properties. This model guides the creation of voxel-level FG structures, resulting in two biomimetic constructs mimicking specific bone-soft tissue interfaces with superior mechanical properties. Additionally, the model studies the FG influence on murine preosteoblast and human bone marrow-derived mesenchymal stromal cell (hBMSC) morphology and protein expression, driving rational design of soft-hard interfaces in biomedical applications.

Original language	English
Article number	101552
Number of pages	24
Journal	Cell Reports Physical Science
Volume	4
Issue number	9
DOIs	https://doi.org/10.1016/j.xcrp.2023.101552
Publication status	Published - 2023

Keywords

bio-inspired composites
functional gradients
interface tissue engineering
regenerative medicine
soft-hard interfaces
voxel-by-voxel 3D printing

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10.1016/j.xcrp.2023.101552

1-s2.0-S2666386423003491-mainFinal published version, 6.21 MBLicence: CC BY-NC-ND

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Saldívar, M. C., Veeger, R. P. E., Tay, E., Fenu, M., Klimopoulou, M., van Osch, G., Fratila-Apachitei, L., Doubrovski, Z., Mirzaali, M. J., Zadpoor, A. A., & More Authors (2023). Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces. Cell Reports Physical Science, 4(9), Article 101552. https://doi.org/10.1016/j.xcrp.2023.101552

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abstract = "Living organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D-printed voxels from either hard or soft phase to decode this relationship. Combining micro/macroscale experiments and finite element simulations, a power law model emerges, linking voxel arrangement to composite properties. This model guides the creation of voxel-level FG structures, resulting in two biomimetic constructs mimicking specific bone-soft tissue interfaces with superior mechanical properties. Additionally, the model studies the FG influence on murine preosteoblast and human bone marrow-derived mesenchymal stromal cell (hBMSC) morphology and protein expression, driving rational design of soft-hard interfaces in biomedical applications.",

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author = "Sald{\'i}var, {Mauricio Cruz} and Veeger, {Robin Petrus Elias} and Edwin Tay and Michele Fenu and Maria Klimopoulou and {van Osch}, Gerjo and Lidy Fratila-Apachitei and Zjenja Doubrovski and Mirzaali, {Mohammad Javad} and Zadpoor, {Amir Abbas} and {More Authors}",

year = "2023",

doi = "10.1016/j.xcrp.2023.101552",

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AU - Saldívar, Mauricio Cruz

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AU - Tay, Edwin

AU - Fenu, Michele

AU - Klimopoulou, Maria

AU - van Osch, Gerjo

AU - Fratila-Apachitei, Lidy

AU - Doubrovski, Zjenja

AU - Mirzaali, Mohammad Javad

AU - Zadpoor, Amir Abbas

AU - More Authors, null

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N2 - Living organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D-printed voxels from either hard or soft phase to decode this relationship. Combining micro/macroscale experiments and finite element simulations, a power law model emerges, linking voxel arrangement to composite properties. This model guides the creation of voxel-level FG structures, resulting in two biomimetic constructs mimicking specific bone-soft tissue interfaces with superior mechanical properties. Additionally, the model studies the FG influence on murine preosteoblast and human bone marrow-derived mesenchymal stromal cell (hBMSC) morphology and protein expression, driving rational design of soft-hard interfaces in biomedical applications.

AB - Living organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D-printed voxels from either hard or soft phase to decode this relationship. Combining micro/macroscale experiments and finite element simulations, a power law model emerges, linking voxel arrangement to composite properties. This model guides the creation of voxel-level FG structures, resulting in two biomimetic constructs mimicking specific bone-soft tissue interfaces with superior mechanical properties. Additionally, the model studies the FG influence on murine preosteoblast and human bone marrow-derived mesenchymal stromal cell (hBMSC) morphology and protein expression, driving rational design of soft-hard interfaces in biomedical applications.

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KW - functional gradients

KW - interface tissue engineering

KW - regenerative medicine

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Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces

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