Scale-up/Scale-down of microbial bioprocesses: a modern light on an old issue

Frank Delvigne*, Henk Noorman

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)
29 Downloads (Pure)


The bio-economy is in transit from innovation to commercialization. The bioprocess industry is expected to increasingly deliver bio-products to the market, in large amounts, at high quality and at competitive cost levels. This requires flawless start-up of new large-scale bioprocesses and continuous improvement of running processes. Fermentation scale-up and operation can benefit from recent advances in three areas: 1. computation-driven design of scale-down simulators, 2. omics-driven metabolic engineering and 3. sensing and understanding of population heterogeneity. Integration of these fields requires a unified computational approach, linked to big data and simulated reality frameworks, of which the contours are becoming visible today.

Original languageEnglish
Pages (from-to)685-687
Number of pages3
JournalMicrobial Biotechnology
Issue number4
Publication statusPublished - 2017

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