Selective Activation of C−H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis

Wuyuan Zhang, Bastien O. Burek, Elena Fernández-Fueyo, Miguel Alcalde, Jonathan Z. Bloh, Frank Hollmann

Research output: Contribution to journalArticleScientificpeer-review

54 Citations (Scopus)
39 Downloads (Pure)

Abstract

Selective oxyfunctionalizations of inert C−H bonds can be achieved under mild conditions by using peroxygenases. This approach, however, suffers from the poor robustness of these enzymes in the presence of hydrogen peroxide as the stoichiometric oxidant. Herein, we demonstrate that inorganic photocatalysts such as gold–titanium dioxide efficiently provide H2O2 through the methanol-driven reductive activation of ambient oxygen in amounts that ensure that the enzyme remains highly active and stable. Using this approach, the stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol was achieved with high enantioselectivity (>98 % ee) and excellent turnover numbers for the biocatalyst (>71 000).

Original languageEnglish
Pages (from-to)15451-15455
Number of pages5
JournalAngewandte Chemie (International Edition)
Volume56
Issue number48
DOIs
Publication statusPublished - 27 Nov 2017

Keywords

  • Biocatalysis
  • oxyfunctionalization
  • peroxygenases
  • photocatalysis
  • TiO

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