@inproceedings{e41f43a8dd5743949a6361a7d05f99c9,
title = "Simulation-based validation of the physical model in 3D polarized light imaging",
abstract = "3D Polarized Light Imaging is a neuroimaging technique that provides a high-resolution reconstruction of nerve fiber pathways in human postmortem brains. The spatial fiber orientations are derived from birefringence measurements of histological brain sections which are interpreted by a macroscopic model of uniaxial birefringence. In order to validate the macroscopic model and to investigate possible limitations, numerical simulations have been used. Simulations of a fiber bundle with different inclination angles and optical resolutions have shown that the macroscopic model ensures a reliable estimation of the fiber orientations as long as the polarimeter does not resolve structures smaller than the fiber radius.",
author = "Miriam Menzel and Melanie Dohmen and {De Raedt}, Hans and Kristel Michielsen and Katrin Amunts and Markus Axer",
year = "2015",
language = "English",
series = "Novel Techniques in Microscopy, NTM 2015",
publisher = "OSA - The Optical Society",
booktitle = "Novel Techniques in Microscopy, NTM 2015",
address = "United States",
note = "Novel Techniques in Microscopy, NTM 2015 ; Conference date: 12-04-2015 Through 15-04-2015",
}