Studying genomic processes at the single-molecule level: introducing the tools and applications

D Dulin, J Lipfert, MC Moolman, NH Dekker

Research output: Contribution to journalArticleScientificpeer-review

61 Citations (Scopus)
32 Downloads (Pure)

Abstract

To understand genomic processes such as transcription, translation or splicing, we need to be able to study their spatial and temporal organization at the molecular level. Single-molecule approaches provide this opportunity, allowing researchers to monitor molecular conformations, interactions or diffusion quantitatively and in real time in purified systems and in the context of the living cell. This Review introduces the types of application of single-molecule approaches that can enhance our understanding of genome function.
Original languageEnglish
Pages (from-to)9-22
Number of pages14
JournalNature Reviews. Genetics
Volume14
Issue number1
DOIs
Publication statusPublished - 2013

Bibliographical note

Accepted Author Manuscript

Keywords

  • Gene expression
  • Genomics
  • Microbial genetics
  • Technology

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