Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy

Philipp Droop, Shaohuang Chen, Melissa J. Radford, Elisabeth Paulssen, Byron D. Gates, Raymond M. Reilly, Valery Radchenko, Cornelia Hoehr*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 » h and 64.1 » h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 » nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 » μg (gold)/mL with an activity of 151 ± 93 » kBq/mL (197gHg, time corrected to the end of bombardment).

Original languageEnglish
Pages (from-to)773-779
Number of pages7
JournalRadiochimica Acta
Volume111
Issue number10
DOIs
Publication statusPublished - 2023

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

  • Hg
  • gold nanoparticle (AuNP)
  • Meitner-Auger-electron (MAE)
  • targeted radionuclide therapy (TRT)

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