The Development of Tungsten Biochemistry-A Personal Recollection

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Abstract

The development of tungsten biochemistry is sketched from the viewpoint of personal participation. Following its identification as a bio-element, a catalogue of genes, enzymes, and reactions was built up. EPR spectroscopic monitoring of redox states was, and remains, a prominent tool in attempts to understand tungstopterin-based catalysis. A paucity of pre-steady-state data remains a hindrance to overcome to this day. Tungstate transport systems have been characterized and found to be very specific for W over Mo. Additional selectivity is presented by the biosynthetic machinery for tungstopterin enzymes. Metallomics analysis of hyperthermophilic archaeon Pyrococcus furiosus indicates a comprehensive inventory of tungsten proteins.

Original languageEnglish
Article number4017
Number of pages18
JournalMolecules (Basel, Switzerland)
Volume28
Issue number10
DOIs
Publication statusPublished - 2023

Keywords

  • aldehyde oxidoreductase
  • EPR
  • metallomics
  • Pyrococcus furiosus
  • transport
  • tungsten
  • tungstoenzyme
  • tungstopterin

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