The injectable neurostimulator: An emerging therapeutic device

Xiaolong Li, WA Serdijn, Wei Zheng, Yubo Tian, Bing Zhang

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

Injectable neurostimulators are currently applied in clinical trials to minimize the side effects such as discomfort, risk of infection, and post-surgery trauma, which can be pronounced with conventional, bulky implantable neurostimulators. Owing to its smaller
size, wireless-updatable software, and wireless power supply, the injectable neurostimulator is presumably less invasive, ‘smarter’, and has a longer lifetime. We discuss the concept and development of the injectable neurostimulator, persistent implementation challenges, and obstacles to be overcome in its evolution. We survey the use of new materials, technologies, and design methods for injectable electrodes, batteries, antennas, and packaging to enhance reliability and other features. These advances in the field are accompanied by progress in electrophysiology, neuroscience, neurology, clinical trials, and treatments.
Original languageEnglish
Pages (from-to)388-394
Number of pages7
JournalTrends in Biotechnology
Volume33
Issue number7
DOIs
Publication statusPublished - 2015

Keywords

  • biocompatible materials
  • electrical nerve stimulation
  • injectable neurostimulator
  • injectable electronic devices
  • therapeutic device

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