@inproceedings{1121952855474063ba2f5244b4c706c5,
title = "Towards the development of a droplet micro-reactor for industrial relevant screening in biotechnology",
abstract = "We report the development of a droplet-based microfluidic device, which enables long term culturing of microorganisms inside water in oil microdroplets under semi-continuous conditions. Firstly, a microdroplet containing yeast cells is trapped on chip. After an initial incubation phase, this cell laden droplet is coalesced with smaller nutrient droplets to enable cultivation and time-lapsing under semi-continuous conditions. We demonstrate a proof-of-principle study on a sequential batch experiment, which lays a sound foundation for screening of microorganisms under semi-continuous conditions.",
keywords = "Cell growth, Coalescence, Microdroplets, Microfluidics, Nutrient feeding, Screening",
author = "Kartik Totlani and {de Reisse}, Thorben and Maxime Bisschops and {van Gulik}, Walter and Michiel Kreutzer and {van Steijn}, Volkert",
year = "2019",
language = "English",
series = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
publisher = "Chemical and Biological Microsystems Society",
pages = "1005--1006",
booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",
}