Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging

Hans Verstraete, M. Heisler, M.J. Ju, D. Wahl, Laurens Bliek, Jeroen Kalkman, S. Bonora, Y Jian, Michel Verhaegen, M.V. Sarunic

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34 Citations (Scopus)


In this report, which is an international collaboration of OCT, adaptive optics, and control research, we demonstrate the data-based online nonlinear extremum-seeker (DONE) algorithm to guide the image based optimization for wavefront sensorless adaptive optics (WFSL-AO) OCT for in vivo human retinal imaging. The ocular aberrations were corrected using a multi-actuator adaptive lens after linearization of the hysteresis in the piezoelectric actuators. The DONE algorithm succeeded in drastically improving image quality and the OCT signal intensity, up to a factor seven, while achieving a computational time of 1 ms per iteration, making it applicable for many high speed applications. We demonstrate the correction of five aberrations using 70 iterations of the DONE algorithm performed over 2.8 s of continuous volumetric OCT acquisition. Data acquired from an imaging phantom and in vivo from human research volunteers are presented.

Original languageEnglish
Article number#280260
Pages (from-to)2261-2275
JournalBiomedical Optics Express
Issue number4
Publication statusPublished - 2017


  • Active or adaptive optics
  • Algorithms
  • Optical coherence tomography

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