Bi-hormonal Linear Time-Varying Model Predictive Control for Blood Glucose Regulation in Type 1 Diabetes Patients

Dylan Kalisvaart*, Jorge Bonekamp, Sergio Grammatico

*Corresponding author for this work

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

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Abstract

We study predictive control for blood glucose regulation in patients with type 1 diabetes mellitus. We determine optimal control actions for insulin and glucagon infusion via linear time-varying model predictive control (LTV MPC) and dynamic linerization around the state trajectory predicted. Through in silico implementation of a comprehensive nonlinear model, we show that our proposed controller is able to reject meal disturbances, retain normoglycemia afterwards and significantly outperform standard linearized MPC.

Original languageEnglish
Title of host publicationProceedings of the 2023 IEEE Conference on Control Technology and Applications, CCTA 2023
PublisherIEEE
Pages552-558
ISBN (Electronic)979-8-3503-3544-6
DOIs
Publication statusPublished - 2023
Event2023 IEEE Conference on Control Technology and Applications, CCTA 2023 - Bridgetown, Barbados
Duration: 16 Aug 202318 Aug 2023

Conference

Conference2023 IEEE Conference on Control Technology and Applications, CCTA 2023
Country/TerritoryBarbados
CityBridgetown
Period16/08/2318/08/23

Bibliographical note

Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

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