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Abstract
Laboratory synthesis of an elementary biological cell from isolated components may aid in understanding of the fundamental principles of life and will provide a platform for a range of bioengineering and medical applications. In essence, building a cell consists in the integration of cellular modules into system’s level functionalities satisfying a definition of life. To achieve this goal, we propose in this perspective to undertake a semi-rational, system’s level evolutionary approach. The strategy would require iterative cycles of genetic integration of functional modules, diversification of hereditary information, compartmentalized gene expression, selection/screening, and possibly, assistance from open-ended evolution. We explore the underlying challenges to each of these steps and discuss possible solutions toward the bottom-up construction of an artificial living cell.
Original language | English |
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Article number | 927 |
Journal | Frontiers in Bioengineering and Biotechnology |
Volume | 8 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- artificial cell
- bottom-up synthetic biology
- directed evolution
- liposome
- synthetic cell
- system’s level evolution
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Dive into the research topics of 'Roadmap to Building a Cell: An Evolutionary Approach'. Together they form a unique fingerprint.Projects
- 1 Finished
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LEaDing Fellows
Gutierrez, A., Dols Perez, A., Bae, D., Sahoo, H., Wang, W., Lam, K. L., Raimondo, A., Steffelbauer, D. B., Lesne, E. L., Ragno, E., Amador, G. J., Šiaudinyte, L., Sand, M., Robinson Garcia, N., Abil, Z., Purkarthofer, E., Noardo, F., Tasić, J. K., Marin, L., Angeloni, L., loddo, M., Stockill, R. H. J., Franklin, S. W., Hensen, B. J., Dennis, M. J., Afroza Islam, S. T., Kim, T., Manzaneque Garcia, T., Tiringer, U., Marques Penha, F., Esteban Jurado, C., Timmermans, E., McCrum, I. T., Pool, F., Forn-Cuní, G., Will, G., Barrett, H. E., Everett, J. A. C., Kostenzer, J., Luksenburg, J., Hirvasniemi, J., Desai, J., Ruibal, P., Albury, N. J., March, R., Eichengreen, A., Muok, A. R., Cochrane, A., Ravesteijn, B., Riumalló Herl, C. J., Meeusen, C., Biaggi, C., Granger, C., Cecil, C., Fosch Villaronga, E., Sánchez López, E. S., Loehrer, E., da Costa Gonçalves, F., Giardina, F., Wu, H., Gleitz, H. & Khatri, I.
2/01/17 → 1/05/22
Project: Research