Schlieren visualization of focused ultrasound beam steering for spatially specific stimulation of the vagus nerve

S. Kawasaki, E. Dijkema, M. Saccher, Vasiliki Giagka, J.J.H.B. Schleipen, R. Dekker

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

24 Downloads (Pure)

Abstract

In the bioelectronic medicine field, vagus nerve stimulation (VNS) is a promising technique that is expected to treat numerous inflammatory conditions, in addition to the currently FDA approved treatment for epilepsy, depression and obesity [1]. However, current VNS techniques are still limited in the spatial resolution that they can achieve, which limits its therapeutic effect and induces side effects such as coughing, headache and throat pain. In our prior work, we presented a curved ultrasound (US) transducer array with a diameter of 2 mm and with 112 miniature US transducer elements, small enough to be wrapped around the vagus nerve for precise ultrasound nerve stimulation [2]. Due to the curved alignment of the US transducers with 48 of the elements simultaneously excited, the emitted US was naturally focused at the center of the curvature. Building on this work, we employ a beam steering technique to move the focal spot to arbitrary locations within the focal plane of the transducer array. The beam steering was controlled through an in-house built US driver system and was visualized using a pulsed laser schlieren system. The propagation of the US pulse in water was imaged and recorded. This method was found to be a rapid and effective means of visualizing the US propagation.

Original languageEnglish
Title of host publication2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)
PublisherIEEE
Pages1113-1116
Number of pages4
ISBN (Electronic)978-1-7281-4337-8
ISBN (Print)978-1-7281-4338-5
DOIs
Publication statusPublished - 2021
Event10th International IEEE/EMBS Conference on Neural Engineering, NER 2021 - Virtual, Online, Italy
Duration: 4 May 20216 May 2021

Conference

Conference10th International IEEE/EMBS Conference on Neural Engineering, NER 2021
CountryItaly
CityVirtual, Online
Period4/05/216/05/21

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Fingerprint

Dive into the research topics of 'Schlieren visualization of focused ultrasound beam steering for spatially specific stimulation of the vagus nerve'. Together they form a unique fingerprint.

Cite this