Stand-Alone Broad Frequency Range Charge-Balancing System for Neural Stimulators

Jana M.  Späth; Konstantina Kolovou Kouri; Lukas  Holzapfel; Roland  Thewes; Vasiliki Giagka

doi:10.1109/BioCAS58349.2023.10388758

Stand-Alone Broad Frequency Range Charge-Balancing System for Neural Stimulators

Jana M. Späth, Konstantina Kolovou Kouri, Lukas Holzapfel, Roland Thewes, Vasiliki Giagka

Bio-Electronics

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

Abstract

Safety is a critical consideration when designing an electrical neural stimulator, given the direct contact with neural tissue. This paper presents the design of a charge balancing system suitable for frequencies up to the kilohertz domain, to be used as an add-on system for stimulators over a wide range of frequencies, also covering nerve conduction blocking. It operates independently of the stimulator timing by continuously sensing the offset voltage, and applying a corrective current to the electrode, using the offset compensation technique. To ensure its stand-alone capability, the system is battery-powered, and includes a safety and start-up circuit. Electrical measurements verified the functionality of the circuit, demonstrating a residual offset of only 0.7 mV for 1 V biphasic pulses at 50 kHz. When tested for 20 kHz biphasic pulse at a 5 V amplitude, the offset was measured at -11.6 mV, which is still within the (commonly used) ±50 mV safety window.

Original language	English
Title of host publication	Proceedings of the 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Place of Publication	Danvers
Publisher	IEEE
Number of pages	5
ISBN (Electronic)	979-8-3503-0026-0
ISBN (Print)	979-8-3503-0027-7
DOIs	https://doi.org/10.1109/BioCAS58349.2023.10388758
Publication status	Published - 2023
Event	2023 IEEE Biomedical Circuits and Systems Conference (BioCAS) - Toronto, Canada Duration: 19 Oct 2023 → 21 Oct 2023

Conference

Conference	2023 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Country/Territory	Canada
City	Toronto
Period	19/10/23 → 21/10/23

Bibliographical note

Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

neural stimulation
active charge balancing
offset compensation
kilohertz frequency alternating current (KHFAC)

Access to Document

10.1109/BioCAS58349.2023.10388758

Cite this

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title = "Stand-Alone Broad Frequency Range Charge-Balancing System for Neural Stimulators",

abstract = "Safety is a critical consideration when designing an electrical neural stimulator, given the direct contact with neural tissue. This paper presents the design of a charge balancing system suitable for frequencies up to the kilohertz domain, to be used as an add-on system for stimulators over a wide range of frequencies, also covering nerve conduction blocking. It operates independently of the stimulator timing by continuously sensing the offset voltage, and applying a corrective current to the electrode, using the offset compensation technique. To ensure its stand-alone capability, the system is battery-powered, and includes a safety and start-up circuit. Electrical measurements verified the functionality of the circuit, demonstrating a residual offset of only 0.7 mV for 1 V biphasic pulses at 50 kHz. When tested for 20 kHz biphasic pulse at a 5 V amplitude, the offset was measured at -11.6 mV, which is still within the (commonly used) ±50 mV safety window.",

keywords = "neural stimulation, active charge balancing, offset compensation, kilohertz frequency alternating current (KHFAC)",

author = "Sp{\"a}th, {Jana M.} and {Kolovou Kouri}, Konstantina and Lukas Holzapfel and Roland Thewes and Vasiliki Giagka",

note = "Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.; 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS) ; Conference date: 19-10-2023 Through 21-10-2023",

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Späth, JM, Kolovou Kouri, K , Holzapfel, L, Thewes, R & Giagka, V 2023, Stand-Alone Broad Frequency Range Charge-Balancing System for Neural Stimulators. in Proceedings of the 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS). IEEE, Danvers, 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS), Toronto, Canada, 19/10/23. https://doi.org/10.1109/BioCAS58349.2023.10388758

Stand-Alone Broad Frequency Range Charge-Balancing System for Neural Stimulators. / Späth, Jana M. ; Kolovou Kouri, Konstantina ; Holzapfel, Lukas et al.
Proceedings of the 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS). Danvers: IEEE, 2023.

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

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AU - Holzapfel, Lukas

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AU - Giagka, Vasiliki

N1 - Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

PY - 2023

Y1 - 2023

N2 - Safety is a critical consideration when designing an electrical neural stimulator, given the direct contact with neural tissue. This paper presents the design of a charge balancing system suitable for frequencies up to the kilohertz domain, to be used as an add-on system for stimulators over a wide range of frequencies, also covering nerve conduction blocking. It operates independently of the stimulator timing by continuously sensing the offset voltage, and applying a corrective current to the electrode, using the offset compensation technique. To ensure its stand-alone capability, the system is battery-powered, and includes a safety and start-up circuit. Electrical measurements verified the functionality of the circuit, demonstrating a residual offset of only 0.7 mV for 1 V biphasic pulses at 50 kHz. When tested for 20 kHz biphasic pulse at a 5 V amplitude, the offset was measured at -11.6 mV, which is still within the (commonly used) ±50 mV safety window.

AB - Safety is a critical consideration when designing an electrical neural stimulator, given the direct contact with neural tissue. This paper presents the design of a charge balancing system suitable for frequencies up to the kilohertz domain, to be used as an add-on system for stimulators over a wide range of frequencies, also covering nerve conduction blocking. It operates independently of the stimulator timing by continuously sensing the offset voltage, and applying a corrective current to the electrode, using the offset compensation technique. To ensure its stand-alone capability, the system is battery-powered, and includes a safety and start-up circuit. Electrical measurements verified the functionality of the circuit, demonstrating a residual offset of only 0.7 mV for 1 V biphasic pulses at 50 kHz. When tested for 20 kHz biphasic pulse at a 5 V amplitude, the offset was measured at -11.6 mV, which is still within the (commonly used) ±50 mV safety window.

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BT - Proceedings of the 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS)

PB - IEEE

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T2 - 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS)

Y2 - 19 October 2023 through 21 October 2023

ER -

Stand-Alone Broad Frequency Range Charge-Balancing System for Neural Stimulators

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