Research Output per year
Research Output
2020
Adsorption Sequencing as a Rapid Method to Link Environmental Bacteriophages to Hosts
de Jonge, P. A., von Meijenfeldt, F. A. B., Costa, A. R., Nobrega, F. L., Brouns, S. J. J. & Dutilh, B. E., 2020, In : iScience. 23, 9, 101439.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
An educational guide for nanopore sequencing in the classroom
Salazar, A. N., Nobrega, F. L., Anyansi, C., Aparicio-Maldonado, C., Costa, A. R., Haagsma, A. C., Hiralal, A., Mahfouz, A., McKenzie, R. E., van Rossum, T., Brouns, S. J. J. & Abeel, T., 2020, In : PLoS Computational Biology. 16, 1, p. e1007314 7 p., e1007314.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
1
Citation
(Scopus)
81
Downloads
(Pure)
Direct Visualization of Native CRISPR Target Search in Live Bacteria Reveals Cascade DNA Surveillance Mechanism
Vink, J. N. A., Martens, K. J. A., Vlot, M., McKenzie, R. E., Almendros, C., Estrada Bonilla, B., Brocken, D. J. W., Hohlbein, J. & Brouns, S. J. J., 2020, In : Molecular Cell. 77, 1, p. 39-50.e10Research output: Contribution to journal › Article › Scientific › peer-review
5
Citations
(Scopus)
Mining moon & mars with microbes: Biological approaches to extract iron from Lunar and Martian regolith
Volger, R., Pettersson, G. M., Brouns, S. J. J., Rothschild, L. J., Cowley, A. & Lehner, B. A. E., 2020, In : Planetary and Space Science. 184, 9 p., 104850.Research output: Contribution to journal › Article › Scientific › peer-review
Selective loading and processing of prespacers for precise CRISPR adaptation
Kim, S., Loeff, L., Colombo, S., Jergic, S., Brouns, S. J. J. & Joo, C., 2020, In : Nature. 579, 7797, p. 141-145 5 p.Research output: Contribution to journal › Article › Scientific › peer-review
3
Citations
(Scopus)
2019
Cas4-Cas1 fusions drive efficient PAM selection and control CRISPR adaptation
Almendros, C., Nobrega, F. L., McKenzie, R. E. & Brouns, S. J. J., 2019, In : Nucleic Acids Research. 47, 10, p. 5223-5230Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
6
Citations
(Scopus)
56
Downloads
(Pure)
Coacervate-based detection of a compound of interest
Brouns, S., Reese, L. & Spoelstra, K., 2019, IPC No. C12Q, Priority date 20 Oct 2017, Priority No. NL2019775Research output: Patent
Conserved motifs in the CRISPR leader sequence control spacer acquisition levels in Type I-D CRISPR-Cas systems
Kieper, S. N., Almendros, C. & Brouns, S. J. J., 2019, In : FEMS Microbiology Letters. 366, 11, 5 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
3
Citations
(Scopus)
48
Downloads
(Pure)
Creation of Conductive Graphene Materials by Bacterial Reduction Using Shewanella Oneidensis
Lehner, B. A. E., Janssen, V. A. E. C., Spiesz, E. M., Benz, D., Brouns, S. J. J., Meyer, A. S. & van der Zant, H. S. J., 2019, In : ChemistryOpen. 8, 7, p. 888-895Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
3
Citations
(Scopus)
49
Downloads
(Pure)
CRISPR-Cas Systems Reduced to a Minimum
Almendros, C., Kieper, S. N. & Brouns, S. J. J., 21 Feb 2019, In : Molecular Cell. 73, 4, p. 641-642Research output: Contribution to journal › Review article › Scientific › peer-review
End-to-end mission design for microbial ISRU activities as preparation for a moon village
Lehner, B. A. E., Schlechten, J., Filosa, A., Canals Pou, A., Mazzotta, D. G., Spina, F., Tjon, S. Y., Meyer, A. S., Brouns, S. J. J. & More Authors, 2019, In : Acta Astronautica. 162, p. 216-226Research output: Contribution to journal › Article › Scientific › peer-review
2
Citations
(Scopus)
Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
Makarova, K. S., Wolf, Y. I., Iranzo, J., Shmakov, S. A., Alkhnbashi, O. S., Brouns, S. J. J., Charpentier, E., Cheng, D., Shah, S. A. & More Authors, 2019, In : Nature Reviews Microbiology. 17 p.Research output: Contribution to journal › Review article › Scientific › peer-review
42
Citations
(Scopus)
Evolution of BACON Domain Tandem Repeats in crAssphage and Novel Gut Bacteriophage Lineages
Jonge, P. A. D., Meijenfeldt, F. A. B. V., Rooijen, L. E. V., Brouns, S. J. J. & Dutilh, B. E., 2019, In : Viruses. 11, 12, 17 p., v11121085.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
3
Citations
(Scopus)
20
Downloads
(Pure)
Global phylogeography and ancient evolution of the widespread human gut virus crAssphage
Edwards, R. A., Vega, A. A., Dutilh, B. E., Norman, H. M., Ohaeri, M. C., Levi, K., Brouns, S., de Jonge, P., Luzia De Nóbrega, F. & More Authors, 2019, In : Nature Microbiology. 4, 10, p. 1727-1736Research output: Contribution to journal › Article › Scientific › peer-review
22
Citations
(Scopus)
Harnessing type I CRISPR–Cas systems for genome engineering in human cells
Cameron, P., Coons, M. M., Klompe, S. E., Lied, A. M., Smith, S. C., Vidal, B., Kennedy, R., Brouns, S. J. J. & More Authors, 2019, In : Nature Biotechnology. 37, 12, p. 1471-1477 7 p.Research output: Contribution to journal › Letter › Scientific › peer-review
9
Citations
(Scopus)
Molecular and Evolutionary Determinants of Bacteriophage Host Range
de Jonge, P. A., Nobrega, F. L., Brouns, S. J. J. & Dutilh, B. E., 1 Jan 2019, In : Trends in Microbiology. 27, 1, p. 51-63 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
34
Citations
(Scopus)
Systematic analysis of Type I-E Escherichia coli CRISPR-Cas PAM sequences ability to promote interference and primed adaptation
Musharova, O., Sitnik, V., Vlot, M., Savitskaya, E., Datsenko, K. A., Krivoy, A., Fedorov, I., Semenova, E., Brouns, S. J. J. & Severinov, K., 2019, In : Molecular Microbiology. 111, 6, p. 1558-1570Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
4
Citations
(Scopus)
50
Downloads
(Pure)
Using CAPTURE to detect spacer acquisition in native CRISPR arrays
McKenzie, R. E., Almendros, C., Vink, J. N. A. & Brouns, S. J. J., 2019, In : Nature Protocols. 14, 3, p. 976-990Research output: Contribution to journal › Article › Scientific › peer-review
3
Citations
(Scopus)
Visualisation of dCas9 target search in vivo using an open-microscopy framework
Martens, K., van Beljouw, S. P. B., van der Els, S., Vink, J. N. A., Baas, S., Vogelaar, G. A., Brouns, S. J. J., van Baarlen, P., Kleerebezem, M. & Hohlbein, J., 2019, In : Nature Communications. 10, 1, 11 p., 3552.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
7
Citations
(Scopus)
48
Downloads
(Pure)
2018
Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes
Vlot, M., Houkes, J., Lochs, S. J. A., Swarts, D. C., Zheng, P., Kunne, T., Mohanraju, P., Anders, C., Jinek, M., Van Der Oost, J., Dickman, M. J. & Brouns, S. J. J., 2018, In : Nucleic Acids Research. 46, 2, p. 873-885 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
14
Citations
(Scopus)
35
Downloads
(Pure)
Cas4 Facilitates PAM-Compatible Spacer Selection during CRISPR Adaptation
Kieper, S. N., Almendros, C., Behler, J., McKenzie, R. E., Luzia De Nóbrega, F., Haagsma, A. C., Vink, J. N. A., Hess, W. R. & Brouns, S. J. J., 2018, In : Cell Reports. 22, 13, p. 3377-3384 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
37
Citations
(Scopus)
16
Downloads
(Pure)
Complete genome sequence of the Escherichia coli phage Ayreon
Vlot, M., Nobrega, F. L., Wong, C. F. A., Liu, Y. & Brouns, S. J. J., 2018, In : Genome Announcements. 6, 2, e01354-17.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Complete genome sequences of two T4-like Escherichia coli bacteriophages
Costa, A. R., Brouns, S. J. J. & Nobrega, F. L., 1 Jun 2018, In : Genome Announcements. 6, 26, e00586-18.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
1
Citation
(Scopus)
22
Downloads
(Pure)
Repetitive DNA Reeling by the Cascade-Cas3 Complex in Nucleotide Unwinding Steps
Loeff, L., Brouns, S. J. J. & Joo, C., 2018, In : Molecular Cell. 70, 3, p. 385-394.e3Research output: Contribution to journal › Article › Scientific › peer-review
20
Citations
(Scopus)
Role of nucleotide identity in effective CRISPR target escape mutations
Künne, T., Zhu, Y., da Silva, F., Konstantinides, N., McKenzie, R. E., Jackson, R. N. & Brouns, S. J., 2018, In : Nucleic Acids Research. 46, 19, p. 10395-10404Research output: Contribution to journal › Article › Scientific › peer-review
3
Citations
(Scopus)
Targeting mechanisms of tailed bacteriophages
Nobrega, F. L., Vlot, M., de Jonge, P. A., Dreesens, L. L., Beaumont, H. J. E., Lavigne, R., Dutilh, B. E. & Brouns, S. J. J., 2018, In : Nature Reviews Microbiology. 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
52
Citations
(Scopus)
2017
CRISPR-Cas: Adapting to change
Jackson, S. A., McKenzie, R. E., Fagerlund, R. D., Kieper, S. N., Fineran, P. C. & Brouns, S. J. J., 7 Apr 2017, In : Science. 356, 6333, p. 1-9 9 p., eaal5056.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
127
Citations
(Scopus)
87
Downloads
(Pure)
2016
Cas3-Derived Target DNA Degradation Fragments Fuel Primed CRISPR Adaptation
Künne, T., Kieper, S. N., Bannenberg, J. W., Vogel, A. I. M., Miellet, W. R., Klein, M., Depken, M., Suarez-Diez, M. & Brouns, S. J. J., 1 Sep 2016, In : Molecular Cell. 63, 5, p. 852-864 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
61
Citations
(Scopus)
147
Downloads
(Pure)
2015
Two distinct DNA binding modes guide dual roles of a CRISPR-cas protein complex
Blosser, T. R., Loeff, L., Westra, E. R., Vlot, M., Künne, T., Sobota, M., Dekker, C., Brouns, S. J. J. & Joo, C., 2015, In : Molecular Cell. 58, 1, p. 60-70Research output: Contribution to journal › Article › Scientific › peer-review
65
Citations
(Scopus)